pentobarbital will minimize the extent or influence of guanfacine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Powerful or moderate CYP3A4 inducers drastically decrease guanfacine plasma concentrations and elimination 50 %-daily life.pentobarbital will lessen the level or influence of bortezomib by impac… Read More